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Emphasis: Bold and Italic

1. Do you know the origin and date of creation of the bold style?
I read it was dated XVIth century. I don't know the precise date and who used to initiate it?
2. Apart from the creation of italic as a specific typeface by Alde Manuce and Francesco Griffo in the very beginning of XVIth century, when was italic first used as a way of highlighting a reference or a single word inside a paragraph?