I am trying to design a book for a customer. It's non-fiction, perhaps one or two images, otherwise it's text with maybe two levels of hierarchy. The body text alternates between quoting from an old religious text and explanatory comments. Sometimes these alternations stretch over a page or more, sometimes they're only a line or two.
For the body text, the latest proposal was to alternate between normal and italic of the same type and weight, a solution which I found comfortable to read. Setting the old religious text a little "poem style" (indented, italic, ragged right) and the explanatory comment as just reading text (no indent, normal, justified) I found quite pleasing.